I started using Venaforce because I was having some serious leg fatigue and swelling in my ankles, so much so that I could hardly walk. I think there are other causes for the swollen ankles, but it has dramatically improved. Also have a family history if varicose veins, although it has only been a minor issue for me. But Venaforce definitely keeps it under control. Have tried another brand of Horse chestnut, but did not get any results. And, being a life-long sufferer of fibromyalgia, IBS accompanies that. So hemorrhoids are almost a given with time. The Venaforce seems to be helpful for that as well. Been taking it regularly since about August, 2x/ day with meal. Still no cure for what ails me, but I have to stick with what I know works!